guaiacolPronunciation: /ˈgwʌɪəkɒl/Definition of guaiacol noun [mass noun] Chemistry an oily yellow liquid with a penetrating odour, obtained by distilling wood tar or guaiac, used as a flavouring and an expectorant. Alternative name: o-methoxyphenol; chemical formula: HOC6H4OCH3 Origin: mid 19th century: from guaiacum + -olguaiacol in other Oxford dictionaries Definition of guaiacol in the US English dictionary