glucagonPronunciation: /ˈgluːkəg(ə)n, -gɒn/Definition of glucagon noun [mass noun] Biochemistry a hormone formed in the pancreas which promotes the breakdown of glycogen to glucose in the liver. Origin: 1920s: from Greek glukus 'sweet' + agōn 'leading, bringing'glucagon in other Oxford dictionaries Definition of glucagon in the US English dictionary