genomePronunciation: /ˈdʒiːnəʊm/Translate genome | into French | into German | into Italian Definition of genome noun [mass noun] Biology the haploid set of chromosomes in a gamete or microorganism, or in each cell of a multicellular organism. the complete set of genes or genetic material present in a cell or organism. Derivatives genomic adjective Origin: 1930s: blend of gene and chromosomegenome in other Oxford dictionaries Definition of genome in the US English dictionary