erythromycinPronunciation: /ɪˌrɪθrə(ʊ)ˈmʌɪsɪn/Definition of erythromycin noun [mass noun] Medicine an antibiotic used in the treatment of infections caused by Gram-positive bacteria. It is similar in its effects to penicillin. This is obtained from the streptomycete bacterium Streptomyces erythreus Origin: 1950s: from elements of the modern Latin taxonomic name (see above) + -in1erythromycin in other Oxford dictionaries Definition of erythromycin in the US English dictionary