epistasisPronunciation: /ɪˈpɪstəsɪs/Definition of epistasis noun [mass noun] Genetics the interaction of genes that are not alleles, in particular the suppression of the effect of one such gene by another. Derivatives epistaticPronunciation: /ˌɛpɪˈstatɪk/ adjective Origin: early 19th century: from Greek, literally 'stoppage', from ephistanai 'to stop'epistasis in other Oxford dictionaries Definition of epistasis in the US English dictionary