endocardiumPronunciation: /ˌɛndəʊˈkɑːdɪəm/Definition of endocardium noun the thin, smooth membrane which lines the inside of the chambers of the heart and forms the surface of the valves. Origin: late 19th century: modern Latin, from endo- 'within' + Greek kardia 'heart'endocardium in other Oxford dictionaries Definition of endocardium in the US English dictionary