dysthymiaPronunciation: /dɪsˈθʌɪmɪə/Definition of dysthymia noun [mass noun] Psychiatry persistent mild depression: in some, at least 2 years of dysthymia lead to recurring major depressionDerivatives dysthymic adjective & noun Origin: mid 19th century: from Greek dusthumiadysthymia in other Oxford dictionaries Definition of dysthymia in the US English dictionary