downerPronunciation: /ˈdaʊnə/Definition of downer noun informal 1 (usually downers) a depressant or tranquillizing drug, especially a barbiturate: during that week I was heavily doped on downers 2a dispiriting or depressing experience or factor:the thought of the danger his son was in put something of a downer on the situation 3a cow or other animal that has fallen down and cannot get to its feet unaided. downer in other Oxford dictionaries Definition of downer in the US English dictionary