diplotenePronunciation: /ˈdɪplətiːn/Definition of diplotene noun [mass noun] Biology the fourth stage of the prophase of meiosis, following pachytene, during which the paired chromosomes begin to separate into two pairs of chromatids. Origin: 1920s: from diplo- 'double' + Greek tainia 'band'diplotene in other Oxford dictionaries Definition of diplotene in the US English dictionary