digoxinPronunciation: /dɪˈdʒɒksɪn/Definition of digoxin noun [mass noun] Chemistry a poisonous compound present in the foxglove and other plants. It is a steroid glycoside and is used in small doses as a cardiac stimulant. Origin: 1930s: contraction of digitoxindigoxin in other Oxford dictionaries Definition of digoxin in the US English dictionary