dermatomePronunciation: /ˈdəːmətəʊm/Definition of dermatome noun Embryology the lateral wall of each somite in a vertebrate embryo, giving rise to the connective tissue of the skin. Compare with myotome, sclerotome. Physiology an area of the skin supplied by nerves from a single spinal root. dermatome in other Oxford dictionaries Definition of dermatome in the US English dictionary