depressivePronunciation: /dɪˈprɛsɪv/Translate depressive | into Italian Definition of depressive adjective causing feelings of severe despondency and dejection. Medicine relating to or tending to suffer from clinical depression:a depressive illness causing a reduction in strength, effectiveness, or value:steroids have a depressive effect on the immune system noun Medicine a person suffering from or with a tendency to suffer from depression. depressive in other Oxford dictionaries Definition of depressive in the US English dictionary