demyelinatePronunciation: /diːˈmʌɪəlɪneɪt/Definition of demyelinate verb [with object] (usually as adjective demyelinating) Medicine cause the loss or destruction of myelin in (nerve tissue):a chronic demyelinating diseaseDerivatives demyelinationPronunciation: /-ˈneɪʃ(ə)n/ noun demyelinate in other Oxford dictionaries Definition of demyelinate in the US English dictionary