cytoskeletonPronunciation: /ˈsʌɪtəʊˌskɛlɪt(ə)n/Definition of cytoskeleton noun Biology a microscopic network of protein filaments and tubules in the cytoplasm of many living cells, giving them shape and coherence. Derivatives cytoskeletalPronunciation: /ˈsʌɪtəʊskɛˈliːt(ə)l/ adjective cytoskeleton in other Oxford dictionaries Definition of cytoskeleton in the US English dictionary