cocainePronunciation: /kə(ʊ)ˈkeɪn/Translate cocaine | into French | into German | into Italian | into Spanish Definition of cocaine noun [mass noun] an addictive drug derived from coca or prepared synthetically, used as an illegal stimulant and sometimes medicinally as a local anaesthetic. Chemical formula: C17H21NO4 Origin: mid 19th century: from coca + -ine4cocaine in other Oxford dictionaries Definition of cocaine in the US English dictionary