co-trimoxazolePronunciation: /ˌkəʊtrʌɪˈmɒksəzəʊl/Definition of co-trimoxazole noun [mass noun] Medicine a mixture of the drugs sulphamethoxazole and trimethoprim, used to treat bacterial infections synergistically. co-trimoxazole in other Oxford dictionaries Definition of co-trimoxazole in the US English dictionary