chylePronunciation: /kʌɪl/Definition of chyle noun [mass noun] Physiology a milky fluid containing fat droplets which drains from the lacteals of the small intestine into the lymphatic system during digestion. Derivatives chylous adjective Origin: late Middle English: from late Latin chylus, from Greek khūlos 'juice' (see chyme)chyle in other Oxford dictionaries Definition of chyle in the US English dictionary