chromatinPronunciation: /ˈkrəʊmətɪn/Definition of chromatin noun [mass noun] Biology the material of which the chromosomes of organisms other than bacteria (i.e. eukaryotes) are composed, consisting of protein, RNA, and DNA. Origin: late 19th century: coined in German from Greek khrōma, khrōmat- 'colour'chromatin in other Oxford dictionaries Definition of chromatin in the US English dictionary