chlorpromazinePronunciation: /klɔːˈprəʊməzɪn, -ziːn/Definition of chlorpromazine noun [mass noun] Medicine a synthetic drug used as a tranquillizer, sedative, and anti-emetic. Origin: 1950s: from chloro- + prom(eth)azinechlorpromazine in other Oxford dictionaries Definition of chlorpromazine in the US English dictionary