chlorhexidinePronunciation: /klɔːˈhɛksɪdiːn/Definition of chlorhexidine noun [mass noun] a synthetic compound used as a mild antiseptic. A biguanide derivative; chemical formula: C22H30Cl2N10 Origin: mid 20th century: from chlor- (representing chlorine) + hex(ane) + -id(e) + (am)ine