centrosomePronunciation: /ˈsɛntrəsəʊm/Definition of centrosome noun Biology an organelle near the nucleus of a cell which contains the centrioles (in animal cells) and from which the spindle fibres develop in cell division. Origin: late 19th century: from Latin centrum (see centre) + Greek sōma 'body'centrosome in other Oxford dictionaries Definition of centrosome in the US English dictionary