centromerePronunciation: /ˈsɛntrə(ʊ)mɪə/Definition of centromere noun Biology the point on a chromosome by which it is attached to a spindle fibre during cell division. Derivatives centromeric adjective Origin: 1920s: from Latin centrum (see centre) + Greek meros 'part'centromere in other Oxford dictionaries Definition of centromere in the US English dictionary