busterPronunciation: /ˈbʌstə/Definition of buster noun informal 1chiefly North American used as a mildly disrespectful form of address to a man or boy:like it or lump it, buster 2 [usually in combination] a person or thing that stops or gets rid of a specified thing:a crime-buster the drug’s reputation as a cold-buster 3a notable or impressive person or thing. a violent gale. buster in other Oxford dictionaries Definition of buster in the US English dictionary