bilirubinPronunciation: /ˌbɪlɪˈruːbɪn/Definition of bilirubin noun [mass noun] Biochemistry an orange-yellow pigment formed in the liver by the breakdown of haemoglobin and excreted in bile. Origin: late 19th century: coined in German from Latin bilis 'bile' + ruber 'red' + -in1bilirubin in other Oxford dictionaries Definition of bilirubin in the US English dictionary