arteriosclerosisPronunciation: /ɑːˌtɪərɪəʊsklɪəˈrəʊsɪs, -sklə-/Definition of arteriosclerosis noun [mass noun] Medicine the thickening and hardening of the walls of the arteries, occurring typically in old age. Derivatives arterioscleroticPronunciation: /-ˈrɒtɪk/ adjective arteriosclerosis in other Oxford dictionaries Definition of arteriosclerosis in the US English dictionary