antipruriticPronunciation: /ˌantɪprʊˈrɪtɪk/Definition of antipruritic adjective (chiefly of a drug) used to relieve itching. noun an antipruritic drug. Origin: late 19th century: from anti- + pruritic (see pruritus)antipruritic in other Oxford dictionaries Definition of antipruritic in the US English dictionary