antigenPronunciation: /ˈantɪdʒ(ə)n/Definition of antigen noun a toxin or other foreign substance which induces an immune response in the body, especially the production of antibodies. Derivatives antigenicPronunciation: /-ˈdʒɛnɪk/ adjective Origin: early 20th century: via German from French antigène (see anti-, -gen)antigen in other Oxford dictionaries Definition of antigen in the US English dictionary