anolePronunciation: /əˈnəʊli/Definition of anole noun a small, mainly arboreal American lizard with a throat fan that (in the male) is typically brightly coloured. Anoles have some ability to change colour. Genus Anolis, family Iguanidae: numerous species Origin: early 18th century: from Caribanole in other Oxford dictionaries Definition of anole in the US English dictionary