androstenedionePronunciation: /ˌandrɒstiːnˈdaɪəʊn/Definition of androstenedione noun [mass noun] an androgenic steroid from which testosterone and certain oestrogens are derived in humans. Origin: 1930s: from androsterone + -ene + di-1 + -oneandrostenedione in other Oxford dictionaries Definition of androstenedione in the US English dictionary