amolePronunciation: /əˈməʊli/Definition of amole noun a plant of a group native to Mexico and the southern US whose roots are used as detergent, especially the soap-plant, Chlorogalum pomeridianum, or the lechuguilla, Agave lecheguilla. Origin: mid 19th century: Mexican Spanishamole in other Oxford dictionaries Definition of amole in the US English dictionary