amitriptylinePronunciation: /ˌamɪˈtrɪptɪliːn/Definition of amitriptyline noun [mass noun] Medicine an antidepressant drug of the tricyclic group, with a mild tranquillizing action. Origin: 1960s: from ami(ne) + tri- + (he)ptyl + -ine4amitriptyline in other Oxford dictionaries Definition of amitriptyline in the US English dictionary