amidePronunciation: /ˈeɪmʌɪd, ˈamʌɪd/Definition of amide noun Chemistry an organic compound containing the group C(O)NH2, derived from ammonia by replacement of a hydrogen atom by an acyl group. a compound derived from ammonia by replacement of a hydrogen atom by a metal, containing the anion NH2−: [with modifier]:sodium amideOrigin: mid 19th century: from ammonia + -ideamide in other Oxford dictionaries Definition of amide in the US English dictionary