allopurinolPronunciation: /ˌalə(ʊ)ˈpjʊərɪnɒl/Definition of allopurinol noun [mass noun] Medicine a synthetic drug which inhibits uric acid formation, used to treat gout and related conditions. Origin: 1960s: from allo- 'other' + purine + -olallopurinol in other Oxford dictionaries Definition of allopurinol in the US English dictionary