actomyosinPronunciation: /ˌaktə(ʊ)ˈmʌɪəsɪn/Definition of actomyosin noun [mass noun] Biochemistry a complex of actin and myosin of which the contractile protein filaments of muscle tissue are composed. Origin: 1940s: from actin + myosinactomyosin in other Oxford dictionaries Definition of actomyosin in the US English dictionary