Titicaca, LakePronunciation: /ˌtɪtɪˈkɑːkɑː/Definition of Titicaca, Lake a lake in the Andes, on the border between Peru and Bolivia. At an altitude of 3,809 m (12,497 ft), it is the highest large lake in the world. Titicaca, Lake in other Oxford dictionaries Definition of Titicaca, Lake in the US English dictionary