Santo DomingoPronunciation: /ˌsantəʊ dəˈmɪŋgəʊ/Definition of Santo Domingo the capital of the Dominican Republic, a port on the south coast; population 2,154,000 (est. 2007). From 1936 to 1961 it was called Ciudad Trujillo. Santo Domingo in other Oxford dictionaries Definition of Santo Domingo in the US English dictionary