Peyer's patchesPronunciation: /ˈpʌɪəz/Definition of Peyer's patches noun Anatomy the numerous areas of lymphoid tissue in the wall of the small intestine which are involved in the development of immunity to antigens present there. Origin: mid 19th century: named after Johann K. Peyer (1653–1712), Swiss anatomistPeyer's patches in other Oxford dictionaries Definition of Peyer's patches in the US English dictionary