NewcastlePronunciation: /ˈnjuːkɑːs(ə)l/Definition of Newcastle 1an industrial city and metropolitan district in NE England, a port on the River Tyne; population 170,200 (est. 2009). Full name Newcastle upon Tyne. 2an industrial town in Staffordshire, in England, just south-west of Stoke-on-Trent; population 77,500 (est. 2009). Full name Newcastle-under-Lyme. 3an industrial port on the SE coast of Australia, in New South Wales; population 152,659 (2008). Newcastle in other Oxford dictionaries Definition of Newcastle in the US English dictionary