an ancient region of SW Asia in present-day Iraq, lying between the Rivers Tigris and Euphrates. Its alluvial plains were the site of the civilizations of Akkad, Sumer, Babylonia, and Assyria.
Derivatives
Mesopotamian
adjective & noun
Origin:
from Greek mesos 'middle' + potamos 'river'
Mesopotamia in other Oxford dictionaries
Definition of Mesopotamia in the US English dictionary