MedePronunciation: /miːd/Definition of Mede noun a member of an Indo-European people who inhabited ancient Media, establishing an extensive empire during the 7th century bc. Phrases law of the Medes and Persians something which cannot be altered: God’s laws of nature were like those of the Medes and the Persians, which changed not[with biblical allusion to Dan. vi. 12]Origin:from Latin Medi, Greek Mēdoi, plural formsMede in other Oxford dictionaries Definition of Mede in the US English dictionary