ManassehPronunciation: /məˈnasi, -ˈnasə/Definition of Manasseh (in the Bible) the elder son of Joseph, ancestor of the tribe of Manasseh (Gen. 48:19). the tribe of Israel traditionally descended from Manasseh, which settled on both sides of the River Jordan. Manasseh in other Oxford dictionaries Definition of Manasseh in the US English dictionary