Lou Gehrig's diseasePronunciation: /luːˈɡɛːrɪɡzdɪziːz/Definition of Lou Gehrig's disease noun [mass noun] a form of motor neurone disease; amyotrophic lateral sclerosis. Origin: 1940s: named after H. L. Gehrig (see Gehrig, Lou)Lou Gehrig's disease in other Oxford dictionaries Definition of Lou Gehrig's disease in the US English dictionary