IowaPronunciation: /ˈʌɪəwə/Definition of Iowa a state in the Middle West of the US, acquired as part of the Louisiana Purchase in 1803; population 3,002,555 (est. 2008); capital, Des Moines. It became the 29th state of the US in 1846. Derivatives Iowan adjective & noun Iowa in other Oxford dictionaries Definition of Iowa in the US English dictionary