Hashimoto's diseasePronunciation: /ˌhaʃɪˈməʊtəʊz/Definition of Hashimoto's disease noun [mass noun] an autoimmune disease causing chronic inflammation and consequential failure of the thyroid gland. Origin: 1930s: named after Hakaru Hashimoto (1881–1934), Japanese surgeonHashimoto's disease in other Oxford dictionaries Definition of Hashimoto's disease in the US English dictionary