EpirusPronunciation: /ɪˈpʌɪərəs/Definition of Epirus a coastal region of NW Greece; capital, Ioánnina. Greek name Ipiros. an ancient country of which the modern region of Epirus corresponds to the south-western part, extending northwards to Illyria and eastwards to Macedonia and Thessaly. Epirus in other Oxford dictionaries Definition of Epirus in the US English dictionary