Durham2Pronunciation: /ˈdʌrəm/Definition of Durham a city on the River Wear; population 42,100 (est. 2009). It is famous for its 11th-century cathedral, which contains the tomb of the Venerable Bede, and its university. (also County Durham) a county of NE England; county town, Durham. Durham in other Oxford dictionaries Definition of Durham in the US English dictionary