CuzcoPronunciation: /ˈkʊskəʊ, ˈkusko, ˈkuθko/Definition of Cuzco a city in the Andes in southern Peru; population 348,900 (est. 2007). It was the capital of the Inca empire until the Spanish conquest in 1533. Cuzco in other Oxford dictionaries Definition of Cuzco in the US English dictionary