ColosseumPronunciation: /ˌkɒləˈsiːəm/Definition of Colosseum noun the name since medieval times of the Amphitheatrum Flavium, a vast amphitheatre in Rome, begun circa 75 ad. Origin:from Latin, neuter of colosseus 'gigantic', from colossus (see colossus)Colosseum in other Oxford dictionaries Definition of Colosseum in the US English dictionary