CayusePronunciation: /ˈkʌɪjuːs/Definition of Cayuse noun (plural same or Cayuses) 1a member of an American Indian people of Washington State and Oregon. 2 [mass noun] the extinct Penutian language of the Cayuse. 3 (cayuse) an American Indian pony. adjective relating to the Cayuse or their language. Origin:the name in Chinook JargonCayuse in other Oxford dictionaries Definition of Cayuse in the US English dictionary