CayugaPronunciation: /ˈkeɪjuːgə, ˈkʌɪ-/Definition of Cayuga noun (plural same or Cayugas) 1a member of an American Indian people, one of the five of the original Iroquois confederacy, formerly inhabiting part of New York State. 2 [mass noun] the extinct Iroquoian language of the Cayuga. adjective relating to the Cayuga or their language. Origin:from an Iroquoian place nameCayuga in other Oxford dictionaries Definition of Cayuga in the US English dictionary